Even with all the interventions and support dedicated towards Syria's healthcare system, there are many challenges standing in the way of the end to the crisis. One challenge reflects the large volume of people affected by the crisis. Billions of people awaiting treatment, rescue, or asylum pose a large challenge for humanitarian organizations as both funds and supplies are limited. As the number of casualties and refugees increase each day, resources are becoming more scarce and interventions are left to face the challenges of the increasing demand. 

Another major challenge, as seen in the video below, reflects the safety of the interventions. The United Nations Security Council has made countless efforts to assure a "safe zone" for aid interventions. Instead, the aid trucks have been targeted by the war parties, leading to their destruction and failed aid delivery. Several war crimes have been assigned to all parties of the war as cases of rape, abuse, starvation, dehydration, and violent murders have been reported throughout the past five years (PHR, 2014). The UN agencies, along with its collaborating partners, are continuously working hard to address the different faces of this complex issue. Finally, the outbreak of diseases such as polio, tuberculosis, and typhoid, have increased due to vaccination drops and unsanitary conditions. Further, deadly disease such as myiasis, never before seen in Syria, have appeared in cases throughout Syria due to the country's unsanitary conditions (PHR, 2014). Infested water and dusty air have caused many illnesses and have brought back many diseases.